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Stem cell therapies for treating horse injuries are still being refined and researched by the lab. Usually, the way we get stem cells from a horse is from their bone marrow in their sternum and then you have to grow the cells for a couple of weeks, so its usually like two to three weeks, Schnabel said. Stem cells that are off the shelf would be ideal in treating horses. One of the long-term-goals of our lab is to develop ways to use MSCs in an off-the-shelf manner, Berglund said. This means that a horse could receive MSCs from a donor at the time of injury or diagnosis of disease instead of waiting weeks until their own cells can be cultured and expanded for use. It was initially thought that stem cells wouldnt cause an immune reaction due to mike mentzer hit training routine how they deregulate immune responses, according to Schnabel. If stem cells from one horse are given to a mismatched horse, then the cells are recognized by the immune system and are targeted for death. This is why the horses used in the lab are immune haplotypes, meaning they can have matched or mismatched stem cell treatments. If theyre getting targeted for death quickly, then theyre probably not going to be as effective. We spent a lot of time isometric holds showing that was true, because thats been debated in the literature for a long time, Schnabel said. Then now were trying to control the immunogenicity of the stem cells so that we could use them in an off-the-shelf way. Tendon injuries generally heal slowly and have scar tissue, and the re-injury rate is high in both horses and humans. Horses, especially racehorses, injure their superficial digital flexor tendons and when they do that, they have a 60 to 70 percent chance of reinjuring that same tendon, according to Schnabel.
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